Viral Myocarditis Death

Saturday, January 9, 2021

Viral myocarditis remains a disease without reliable or effective treatment resulting in chronic dilated cardiomyopathy or death in up to 20 of affected children and 50 of affected adults1Events following viral attachment and replication that produce cytopathic effect and lead to cardiac dysfunction are not clearly understood. Critical role for death-receptor mediated apoptotic signaling in viral myocarditis.

Predictors Of Mortality In Patients With Biopsy Proven Viral Myocarditis 10 Year Outcome Data Journal Of The American Heart Association

Sudden death is the unexpected death of a person due to the cessation of heart function suddenly.

Viral myocarditis death. 20020901 Although viral myocarditis is usually a chronic disease associated with end-stage heart failure it is well documented that it can also be associated with sudden unexpected death 1. It happens due to persistent abnormal electrical activity of the heart that impairs the functioning of the heart leading to heart attacks and heart failure. Blocking the necroptosis pathway may serve as a new therapeutic option for the treatment of acute viral myocarditis.

These findings provide evidence that necroptosis plays a significant role in cardiomyocyte death and it is a major pathway for cell death in acute VMC. Acute viral myocarditis with or without left ventricular dysfunction is an important cause of sudden death in the young. DeBiasi RL1 Robinson BA Leser JS Brown RD Long CS Clarke P.

Myocarditis is the third leading cause of sudden death in young adults. 20191015 Sheetal DeCaria MD. Nevertheless this diagnosis may present difficulties when there are no relevant histological findings using conventional histological stains.

It is well established that viral myocarditis can be associated with sudden unexpected manifestation of death. Coxsackie B3 Myocarditis in 4 Cases of Suspected Sudden Infant Death Syndrome. 20200201 Myocarditis is a major cause of sudden cardiac death SCD and dilated cardiomyopathy DCM in young adults.

20150721 Myocarditisa frequent cause of dilated cardiomyopathy and sudden cardiac deathtypically results from cardiotropic viral infection followed by active inflammatory destruction of the myocardium. 20060131 Determining the etiology of cardiac dysfunction in patients with heart failure influences management and prognosis. 1Department of Pediatrics Childrens National Medical Center and George Washington University School of Medicine Washington DC 20010 USA.

1 Myocarditis diagnosed by the current histopathological Dallas criteria accounts for 10 of patients with new-onset cardiac dysfunction submitted to endomyocardial biopsy. 12 Despite complete evaluation including history physical examination. Pathology - Research and Practice Vol.

SCA may result from either lethal ventricular arrhythmias or damage to the specialized conduction system during the myocarditis. Diagnosis by Immunohistochemical and Molecular-Pathologic Investigations.

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